Advantage II for Dogs Dosage

advantage 2 for dogs box


Advantage II for dogs is available in four products, each corresponding to specific weight ranges of dogs and puppies. There’s one for small dogs (3 to 10 lbs), medium dogs (11 to 20 lbs), large dogs (21 to 55 lbs) and extra large dogs (over 55 lbs). The dosage is higher for heavier dogs. See the dosage by weight chart below. The active ingredient concentration is the same in all four products. View the full product label for application information.


Advantage II for Dogs
Dosage by Weight

Dog WeightMonthly Dose
3 to 10 lbs0.4 mL (0.014 fl oz)
10 to 20 lbs1.0 mL (0.034 fl oz)
21 to 55 lbs2.5 mL (0.085 fl oz)
over 55 lbs4.0 mL (0.135 fl oz)

Advantage II for Dogs
Product Information Chart

Dog Age7 weeks or older
Dog Weightsee chart above
Monthly Dosesee chart above
Killsadults, eggs & larvae
Dose Duration30 days
Ingredients9.1% imidacloprid
0.46% pyriproxyfen
90.44% other ingredients
Product Labelview

Apply the Correct Dosage

Advantage II products are specially formulated and tested for dogs of certain weights. The full dose of the correct product needs to be administered on a monthly basis. The infestation may continue if the manufacturer’s instructions aren’t followed. Don’t under-dose or over-dose pets. Under-dosing commonly occurs when pet owners split treatments between different animals. Toxicity concerns can also lead to under-dosing.

Re-dosing Early

Do not apply more than one tube per treatment, even for larger dogs. Under normal conditions, one dose will last 4 weeks. However, in severe infestations, it may be necessary to retreat the dog earlier in order to attain control. In these situations, do not retreat more often than once every 7 days. Once flea control is established, return to the monthly re-treatment schedule.


Have an unrelated question?

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  • Jodi July 24, 2016, 3:05 pm

    How soon to having pups can I treat a dog?

    • Adam Retzer July 24, 2016, 9:33 pm

      Hello Jodi, this question should be addressed to your veterinarian. However, I’ll provide some relevant information.

      From the product label:
      “Do not use on puppies under 7 weeks of age or weighing less than 3 lbs. As with any product, consult your veterinarian before using this product on debilitated, aged, pregnant or nursing dogs. Individual sensitivities while rare, may occur after using ANY pesticide product for dogs. If signs persist, or become more severe, consult a veterinarian immediately. If your dog is on medication, consult your veterinarian before using this or any other product.”

      Here’s a summary of the reproductive toxicity of imidacloprid (the active ingredient in Advantage):
      Pesticides News No. 62, December 2003, pages 22-23
      Laboratory studies on imidacloprid have shown it can have an impact on reproduction. Imidacloprid fed to pregnant rabbits between the sixth and eighteenth days of pregnancy caused an increase in the frequency of miscarriages and an increase in the number of offspring with abnormal skeletons. These effects were observed at a dose of 72mg/kg per day. In rats, a two-generation feeding study found that rats fed imidacloprid gave birth to smaller offspring; their weight was reduced at a dose of 19 mg/kg per day.

      Imidacloprid – Human Health and Ecological Risk Assessment USDA
      “These studies… were conducted to fulfill EPA requirements for testing as part of the pesticide registration process. In summary, imidacloprid was not found to affect reproductive variables or cause birth defects at doses which did not cause maternal toxicity, when the pregnant animals were exposed via gavage during the critical developmental phases of their pregnancy. However, imidacloprid may adversely affect reproduction and cause developmental delays as a result of maternal toxicity. A developmental neurotoxicity screening study in rats suggests that imidacloprid may also cause neurotoxicity in offspring born to imidacloprid-exposed mothers at doses which do not cause maternal toxicity.”

      Therapy and Prevention of Parasitic Insects in Veterinary Medicine using Imidacloprid
      Dermal application (10% spot-on) to pregnant or lactating bitches up to three times the recommended dosage twice two to four weeks apart did not cause any side effects at various stages of lactation and gestation.

  • patti August 28, 2016, 9:12 pm

    How is it that my dog weight 110 and the chart says to use an extra large dose (55 and over) but it says nothing about a dog that weighs double. I don’t want to make her sick. Do I give her 4.0 or 6.0 or even 8.0. Please help!!!!

    • Adam Retzer August 30, 2016, 12:16 am

      Hello Patti, unfortunately I’m not qualified to answer this question. Your veterinarian can address this question. Alternatively, you can visit Bayer’s contact us page. Here’s the excerpt and phone number found on that page:

      If you have a question about one of our products, please contact a member of our Veterinary Technical Services team at (800) 255-6826.

  • DeAnn Murtle September 11, 2016, 3:04 pm

    Does this product have am experation date?

    • Adam Retzer September 12, 2016, 1:11 pm

      No. There’s no expiration date required by the EPA for Advantage II. It should stay effective if stored in a cool, dry place that is protected from freezing.

  • Jerry brown September 15, 2016, 2:39 pm

    what is the dose per pound for dogs

    • Adam Retzer September 15, 2016, 3:10 pm

      There’s no “dose per pound” measurement. If your dog falls outside of the given specifications on the labels, then it’s best to contact your veterinarian for determining a safe and effective dose.

  • Michele Acosta October 20, 2016, 3:53 pm

    My pup is about 7 pounds 5 months old and I have k9 advantix for medium-sized. My question is could I give her half of the dosage

    • Adam Retzer October 20, 2016, 5:07 pm

      I can’t recommend off-label use of an insecticide product. However, if you look at the dosage chart, the small dog dose is 40% of the dose of the medium dog, not 50%.

  • Leeane October 31, 2016, 7:31 pm

    I have a 7-8 lbs chihuahua that I treated last night and then my daughter treated her today not realizing she had already been treated. What should we do, would it be toxic to her?

    • Adam Retzer November 1, 2016, 4:51 pm

      It’s possible there may be toxic effects. I’d recommend consulting your dog’s veterinarian.

  • Bobbie February 6, 2017, 4:24 am

    My dog was given 5.5 instead of 2.5 ….I did not realize this mistake from my vet….she started getting sores…hair loss…loss of appetite …depression…lethargy…every treatment she was sick…. I brought her to the vet and injection were given antibiotic and cortisone…I asked if it was the advantage and told no… I found an old tube and then seen it was more then double dosage. Last advantage given now has been over a month, how long before it leaves her body and will there be any long term health issuesl I did not take her to the vet after last treatment…
    Thank you
    Bobbie Paquette and Taz

    • Adam Retzer February 6, 2017, 6:13 pm

      The main active ingredient in Advantage II is imidacloprid. You can view our page on this compound: Imidacloprid toxicity. According to the research I’ve seen, any imidacloprid that enters the body will metabolized quickly. It will be completely excreted within 48 hours.

      Most of those adverse symptoms you describe don’t sound like they’re from Advantage, from what I understand. However, I can’t be certain. I am not a veterinarian or expert. I’d suggest contacting your veterinarian again with further concerns. Or you can contact Bayer directly.

  • Lee February 20, 2017, 5:36 pm

    I apply K9 Advantage II monthly to my 90 lb Lab yet I still see fleas on her and they annoy her quite a bit. Should apply more frequently than every 4 weeks? Would it hurt her to also use a spray on her underside and legs?

    • Adam Retzer February 22, 2017, 3:14 pm

      As per the instructions, you can re-treat your dog once every 7 days in severe infestations. However, once control is established, you should return to the monthly re-treatment schedule. I can’t give any specific advice beyond this, as I’m not qualified.

      It’s possible that the dog is sufficiently protected, and you’re just noticing the fleas before they succumb to the insecticide. Usually the imidacloprid kills new fleas within a few hours, but occasionally it can take a bit longer. Use your judgement here to determine if early re-treatment is necessary or not.

      You shouldn’t need to use spray on your dog in conjunction with the Advantage. The Advantage incorporates into the animal’s sebaceous layer. As a result, it gets transported in the dog’s natural oils across the skin and hair. The treatment should cover the dog’s entire body 24 hour after application.

  • Gary Smith March 2, 2017, 5:36 am

    My dog weighs 9 lbs would. .8ml b safe

    • Adam Retzer March 2, 2017, 5:37 pm

      Gary, I can only advise you to follow the labeled directions. Beyond that, I’m not qualified. You may want to consider contacting your dog’s vet if you’re worried that 0.4 mL (small dog product) isn’t sufficient.

  • Nick lietzau April 13, 2017, 9:19 am

    I have a large breed dog, and my girlfriend has a small breed, can I use large breed advantix on her small breed dog?

    • Adam Retzer April 14, 2017, 3:48 pm

      No, it would be too much product. Use the correct product (as per the label) for the dog’s weight.

  • Shirley Murphy April 14, 2017, 5:37 pm

    I bought the Advecta for dogs over 55lb dogs. Can i use it on a 50lb. Dog?

    • Adam Retzer April 21, 2017, 10:11 pm

      The only advice I can give is to adhere to the labeling. Otherwise, you can contact your veterinarian for more specific questions. Unfortunately, I’m legally unable to offer any off-label advice.