There are multiple generic versions of Advantage II for Dogs available. The flea drops on this page are essentially equivalent to Advantage II, with exactly the same active ingredient formulations (9.10% imidacloprid and 0.46% pyriproxyfen).
Combiva II for Dogs
Combiva II is a cheap alternative to Advantage II, with the same ingredients.
Combiva II for Dogs is a cheap alternative to Advantage II that can be found on many popular online retailers. A 3 month package costs around $15 on Amazon. A 4 month supply of Advantage II costs over $50.
Petlock II for Dogs is currently the cheapest generic option available. It isn’t readily available on Amazon, but a 4 month supply can be found on Ebay.com for around $12. It’s also sold in Petco stores for $28, for those who have pets that need treatment immediately and can’t wait for shipping.
Prices and availability are based on the time of publishing and are subject to change. Content on this page is meant for informational purposes only, with no guarantee of accuracy. For full product information visit the manufacturer’s or retailer’s websites. See more disclaimers.
Advantage II for Dogs Active Ingredients
Advantage II for Dogs is formulated with 9.10% imidacloprid and 0.46% pyriproxyfen (Nylar). The generic brands listed below all contain the same active ingredients and in the same concentrations. For complete details, compare the product label of Advantage II for Dogs with the label of the generic alternatives (linked below).
Imidacloprid is an adulticide. It quickly kills adult fleas living on the dog. Pyriproxyfen is an insect growth regulator (IGR). IGRs mimic natural insect hormones that control maturation. IGR-exposed eggs and larvae can’t reach adulthood, and exposed adult females are sterilzed.
Generic Alternatives to Advantage II for Dogs
The products below are listed in order based upon price and availability from popular retailers at the time of publishing.
Combiva II for Dogs
Combiva II for Dogs is a cheap Advantage II alternative, but comes with 3 monthly doses instead of 4. View product label
Combiva II for Dogs and Puppies is a generic brand of Advantage II for Dogs. It contains the same active ingredient concentrations. Combiva II comes in a package of 3 monthly doses (instead of 4 months in Advantage II). There are four products of Combiva II for Dogs, each corresponds to a specific dog weight range. These are 3-10 lbs., 11-20 lbs., 21-55 lbs., and over 55 lbs.
Combiva II is our first choice for a generic alternative to Advantage II, because it’s available at a cheap price from multiple online retailers. On Amazon.com, Combiva II for Dogs can be found for around $15 for a 3 month supply. On Ebay.com, it can be found for a little cheaper, around $12.
PetLock II for Dogs
PetLock II is currently the cheapest generic Advantage II alternative from Ebay.com. View product label
PetLock II for Dogs is another alternative to Advantage II for Dogs. Like the other flea drops listed here, it contains the 9.10% imidacloprid and 0.46% pyriproxyfen. It also comes in four different sizes that correspond to weight ranges of dogs (3-10 lbs., 11-20 lbs., 21-55 lbs., over 55 lbs.).
PetLock II is currently the cheapest version of Advantage II for Dogs. A 4 month supply can be found for around $12 on Ebay.com. The PetLock brand is also carried by Petco (around $28), for those who need to treat their pets right away and can’t wait for shipping.
Adventure Plus for Dogs
Adventure Plus for Dogs is among the least expensive Advantage II equivalents available from Amazon.com. View product label
Adventure Plus for Dogs is generic version of Advantage II for Dogs. It doesn’t significantly differ from those previously listed. It contains the same active ingredients, comes in a 4 month supply, and in 4 different weight ranges.
Adventure Plus stands out as one of the cheapest Advantage II alternatives that’s available on Amazon.com. A four month package costs around $29.
Crossblock II for Dogs
Crossblock II for Dogs is another cheap Advantage II alternative, packaged with 3 doses instead of 4. View product label
CrossBlock II for Dogs flea drops are essentially the same as Combiva II. Both brands are produced by the same parent company, Ceva Animal Health. Both contain the same active ingredient formulation, 3 monthly doses, and have 4 sizes that correspond to different weight ranges of dogs. CrossBlock II is more expensive than Combiva II, and is thus lower on our list.
Sentry Advance Guard2 for Dogs
Sentry Advance Guard2 is another generic version of Advantage II for Dogs. View product label
Sentry Advance Guard2 for Dogs is another Advantage II equivalent. Not much differentiates it from the other flea drops already listed. Sergeant’s Pet Care is the parent company that produces Advance Guard2, as well as PetArmor Advanced 2 (listed below). Both flea drops are essentially the same, but Advance Guard2 is more widely available and thus appears first.
PetArmor Advanced 2 for Dogs
PetArmor Advanced 2 is a different branding of Advance Guard2, as both are produced by Sergeant’s. View product label
DogMD Maximum Defense Advanced 2
DogMD Maximum Defense Advanced 2 is another Advantage II generic name, but is somewhat hard to find. View product label
Advecta II for Dogs
Advecta II for Dogs is an Advantage II alternative that can be found at Walmart and Target. It’s essentially a different branding of PetLock II, as both are produced by PetIQ. View product label