K9 Advantix II Dosage

K9 advantix 2 box


K9 Advantix II is available in four products, each corresponding to specific weight ranges of dogs and puppies. There’s one for small dogs (4 to 10 lbs), medium dogs (11 to 20 lbs), large dogs (21 to 55 lbs) and extra large dogs (over 55 lbs). The applied dose is higher for dogs which weigh more. See the dosage by weight chart below. The formulation of active ingredients is identical in all four products. View the full product label for directions and more information.

Related page: Generic K9 Advantix II has the same active ingredients at less than half the cost.


K9 Advantix II
Dosage by Weight

Dog Weight Monthly Dose
4 to 10 lbs 0.4 mL (0.014 fl oz)
11 to 20 lbs 1.0 mL (0.034 fl oz)
21 to 55 lbs 2.5 mL (0.084 fl oz)
over 55 lbs 4.0 mL (0.135 fl oz)

K9 Advantix II
Product Information Chart

Dog Age 7 weeks or older
Dog Weight see chart above
Monthly Dose see chart above
Kills adults, eggs & larvae
Dose Duration 30 days
Ingredients 8.80% imidacloprid
44.00% permethrin
0.44% pyriproxyfen
46.76% other ingredients
Product Label view
MSDS view
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Apply the Correct Dosage

K9 Advantix II products are specifically formulated and tested for efficacy and safety on dogs of specific weight ranges. The full dose of the correct product needs to be administered on a monthly basis. Control measures may fail if the manufacturer’s instructions on the label aren’t adhered to closely. Don’t under-dose or over-dose pets. Under-dosing sometimes occurs when pet owners split treatments between different dogs. Under-dosing can also arise from toxicity fears.

Re-dosing Early

Don’t apply more than one tube per treatment, even for larger dogs. Under normal circumstances, one dose will last 4 weeks. However, in severe flea infestations, re-treatment is allowable earlier in order to establish control. In these situations, don’t retreat more often than once every 7 days. Once flea control is attained, return to a monthly re-treatment schedule.


Have an unrelated question?

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  • Rebecca Reigle April 5, 2017, 4:53 am

    I accidentally ordered the size up in flea treatment thinking my dog would weigh 55lbs. But he is only about 45lbs. And I gave him the flea treatment. Will he generally be okay?

    • Adam Retzer April 7, 2017, 6:05 pm

      I don’t have the qualifications to answer this question, due to legal liabilities. I’d recommend contacting your dog’s veterinarian to address this concern. Sorry I can’t help more.

  • Sandi April 26, 2017, 6:22 pm

    What is the per pound? If a 55 b dog gets a 2.5 mL dosage, isn’t it that .05 mL per pound. So a 60 lb dog would gt 3 mL – yes or no.

    • Adam Retzer May 2, 2017, 3:06 pm

      There is no specific dose per pound. The dosages are based on four weight ranges, as found on the labeling and in this article. The labeling should be adhered to for dosage. I can’t legally recommend any off-label usage. If you have a question specific to an unusual case, it would be best to contact a veterinarian.

  • George Varshock July 26, 2017, 11:07 pm

    My Rhodesian Ridgeback weighs 130 lbs. Will one tube for dogs over 55 pounds work or should I use two tubes?

    • Adam Retzer July 30, 2017, 7:45 pm

      I am not a licensed professional, and thus can only advise you to adhere to the labeled instructions. If you are worried that this dosage is insufficient, I’d recommend asking your dog’s vet.

  • James August 30, 2017, 10:13 am

    My dog weighs 10.5 lbs. which should I use

    • Adam Retzer September 28, 2017, 3:42 pm

      This is a good question. I’d assume that either the small or medium product would be effective and safe, however I can’t recommend either as I’m not certified to advise off-label use. I’d contact your vet to see which product would be safest and most effective.