K9 Advantix II Dosage

K9 advantix 2 box


K9 Advantix II is available in four products, each corresponding to specific weight ranges of dogs and puppies. There’s one for small dogs (4 to 10 lbs), medium dogs (11 to 20 lbs), large dogs (21 to 55 lbs) and extra large dogs (over 55 lbs). The applied dose is higher for dogs which weigh more. See the dosage by weight chart below. The formulation of active ingredients is identical in all four products. View the full product label for directions and more information.


K9 Advantix II
Dosage by Weight

Dog WeightMonthly Dose
4 to 10 lbs0.4 mL (0.014 fl oz)
11 to 20 lbs1.0 mL (0.034 fl oz)
21 to 55 lbs2.5 mL (0.084 fl oz)
over 55 lbs4.0 mL (0.135 fl oz)

K9 Advantix II
Product Information Chart

Dog Age7 weeks or older
Dog Weightsee chart above
Monthly Dosesee chart above
Killsadults, eggs & larvae
Dose Duration30 days
Ingredients8.80% imidacloprid
44.00% permethrin
0.44% pyriproxyfen
46.76% other ingredients
Product Labelview

Apply the Correct Dosage

K9 Advantix II products are specifically formulated and tested for efficacy and safety on dogs of specific weight ranges. The full dose of the correct product needs to be administered on a monthly basis. Control measures may fail if the manufacturer’s instructions on the label aren’t adhered to closely. Don’t under-dose or over-dose pets. Under-dosing sometimes occurs when pet owners split treatments between different dogs. Under-dosing can also arise from toxicity fears.

Re-dosing Early

Don’t apply more than one tube per treatment, even for larger dogs. Under normal circumstances, one dose will last 4 weeks. However, in severe flea infestations, re-treatment is allowable earlier in order to establish control. In these situations, don’t retreat more often than once every 7 days. Once flea control is attained, return to a monthly re-treatment schedule.


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  • Rebecca Reigle April 5, 2017, 4:53 am

    I accidentally ordered the size up in flea treatment thinking my dog would weigh 55lbs. But he is only about 45lbs. And I gave him the flea treatment. Will he generally be okay?

    • Adam Retzer April 7, 2017, 6:05 pm

      I don’t have the qualifications to answer this question, due to legal liabilities. I’d recommend contacting your dog’s veterinarian to address this concern. Sorry I can’t help more.