Frontline Plus for Cats Dosage

frontline plus for cats box


Frontline Plus for cats is available in one formulation. There aren’t different concentrations for different cat weights. The monthly dosage for cats and kittens is 0.50 mL (0.017 fl oz), which is one full tube. View the full product label for application information.

Related page: Generic Frontline Plus for Cats has the same active ingredients at less than half the cost.


Frontline Plus for Cats
Product Information Chart

Cat Age 8 weeks or older
Cat Weight over 1.5 pounds
Monthly Dose 0.50 mL (0.016907 fl oz)
Kills adults, eggs & larvae
Dose Duration 30 days
Ingredients 9.8% fipronil
11.8% (S)-methoprene
78.4% inert ingredients
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Apply the Correct Dosage

Flea medications can fail if they aren’t applied according to the manufacturer’s directions. These drops are specifically formulated for cats above a certain age and weight. The full dose needs to be administered or the infestation may continue. Under-dosing occurs if treatments are split between multiple pets. Concerns of toxicity can also lead to owners under-dosing their pets.


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  • Jessica Leggett August 11, 2016, 2:37 am

    I have 2 cats. One is a very petite year old rescue and the other is a 12 year old fatness of catness. I am waiting for the Frontline plus in the mail. My question is should I dose the larger cat extra? She weighs about 25 lbs. She is part Maine coon cat. She is huge. I have dosed them both once and the flea problem is just getting worse. I am thinking that the larger cat was underdosed.


    • Adam Retzer August 11, 2016, 11:02 pm

      It’s not uncommon for the flea problem to get worse initially, especially if the infestation went unnoticed for a while. This is because 95-99% of the infestation is composed of eggs, larvae, and pupae in the environment (carpets). So, even if the Frontline Plus kills the adult fleas on your cats, you’ll be seeing new adults emerge from the carpets for up to 8 weeks. Vacuuming regularly can help eliminate the environmental stages.

      Fipronil is the adulticide in Frontline Plus, and it should kill any new fleas that jump onto the cats. The other active ingredient is methoprene, it’s an IGR that sterilizes female fleas, so they can’t lay viable eggs even if they survive the fipronil.

      That said, the fatness of catness (hah!) may be getting underdosed. However, I am not a licensed professional and don’t want to give any instructions that may be harmful to you or your cats. I recommend contacting your veterinarian for off-label use.

  • Elizabeth or Sherwin Wilk April 21, 2017, 11:26 am

    After application of Frontline plus on our 20 lb cat we found 2 attached live ticks on him.
    Our former cat was only 10lb. Is the dose too small? Should we apply another dose?

    • Adam Retzer April 21, 2017, 10:27 pm


      I’m not as familiar with ticks as I am with fleas. And I can’t legally offer off-label advice. According to the label, you shouldn’t apply more than once monthly. Advantage II has early re-dose information on the label, but Frontline doesn’t. These products are similar, but have different ingredients (Advantage doesn’t kill ticks). So early re-dosing may not be an option. Frontline Plus also doesn’t have different dosages for different cat weights.

      I’d recommend contacting your veterinarian for more information, and the’ll be able to assist with specific issues.