Spot-On Flea Drops for Dogs

Kill Fleas on Dogs

Adult fleas are permanent ectoparasites. They have developed a persistent relationship with their hosts and will rarely leave of their own volition.

Topically applied spot-on flea drops for dogs typically contain both an adulticide and an insect growth regulator (IGR). The adulticide (fipronil, imidacloprid, permethrin or dinotefuran) will kill adult fleas on the dog. The IGR (pyriproxyfen or methoprene) will prevent female fleas from laying viable eggs.

frontline plus spot on drops for dogsbayer k9 advantix spot on flea drops for dogsbayer advantage spot on flea drops for dogsvectra spot on flea drops for dogs
Product NameMerial Frontline PlusBayer K9 Advantix IIBayer Advantage IIVectra 3D
Price$40$45$40$45
Size3 tubes4 tubes4 tubes3 tubes
ApplicationSqueeze-OnSqueeze-OnSqueeze-OnSqueeze-On
Use OnDogsDogsDogsDogs
Dog Size5 to 22 lbs
more sizes available
11 to 20 lbs
more sizes available
11 to 20 lbs
more sizes available
11 to 20 lbs
more sizes available
Dog Ageover 8 weeksover 7 weeksover 7 weeksover 8 weeks
KillsEggs
Larvae
Adults
Eggs
Larvae
Adults
Eggs
Larvae
Adults
Eggs
Larvae
Adults
Active Ingredients(S)-Methoprene
Fipronil
Pyriproxyfen
Imidacloprid
Permethrin
Pyriproxyfen
Imidacloprid
Pyriproxyfen
Dinotefuran
Permethrin
A.I. Concentration8.8%
9.8%
0.44%
8.80%
44.00%
0.46%
9.10%
0.44%
4.95%
36.08%
Dose Duration1 month1 months1 months1 months
Total Duration3 month4 months4 months3 months
Product Label
MSDS
FleaScore
Reviewsread reviews
on Amazon.com
read reviews
on Amazon.com
read reviews
on Amazon.com
read reviews
on Amazon.com
  • Prices are approximations based off of Amazon.com prices at the time of publishing.
  • FleaScores are based off of product details (price, size, active ingredients, etc), as well as reviews aggregated from 3rd party sources.
  • (S)-methoprene and pyriproxyfen are insect growth regulators and prevent immature flea stages from reaching adulthood.
  • Pyrethrin is a natural insect neurotoxin. It is an organic compound derived from Chrysanthemum plants.
  • Permethrin and other pyrethroids are synthetic derivatives of natural pyrethrin.
  • Fipronil is a broad-spectrum insecticide that affects an insect’s central nervous system.
  • Imidacloprid and dinotefuran are insect neurotoxins, belonging to the neonicotinoids class of compounds similar to nicotine.

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