2020 Update
I don’t have time to update this whole page, but here is an updated list of available options and prices.
Amazon.com (clickable links)
Least to most expensive per monthly dose (dz)
- Frontline Plus (6 dz): $51.99 ($8.67 / dz)
- Solimo (6 dz): $29.99 ($4.99 / dz)
- PetLock Plus (3 dz): $14.99 ($4.99 / dz)
- PetAction Plus (6 dz): $34.50 ($5.75 / dz)
- FirstAct Plus (3 dz): $17.97 ($5.99 / dz)
- PetArmor Plus (6 dz): $39.50 ($6.58 / dz)
- ZoGuard Plus (6 dz): $39.99 ($6.66 / dz)
- Pet Defender Plus (3 dz): $21.99 ($7.33 / dz)
- FiproGuard Plus (6 dz): $44.99 ($7.50 / dz)
- Direct Protect Plus (3 dz): $24.99 ($8.33 / dz)
- Spectra Sure Plus IGR (3 dz): $24.99 ($8.33 / dz)
- Firstect Plus (3 dz): $31.94 ($10.65 / dz)
eBay.com (clickable links)
Least to most expensive per monthly dose (dz)
- Frontline Plus (6 dz): $34.00 ($5.67 / dz)
- FirstAct Plus (3 dz): $9.99 ($3.33 / dz)
- Direct Protect Plus (3 dz): $9.99 ($3.33 / dz)
- PetArmor Plus (3 dz): $12.99 ($4.33 / dz)
- ZoGuard Plus (3 dz): $12.99 ($4.33 / dz)
- Pet Defender Plus (3 dz): $12.99 ($4.33 / dz)
- PetAction Plus (8 dz): $35.99 ($4.50 / dz)
- PetLock Plus (3 dz): $14.99 ($4.99 / dz)
- DogMD Plus (3 dz): $14.99 ($4.99 / dz)
- Firstect Plus (3 dz): $15.99 ($5.33 / dz)
- FiproGuard Plus (3 dz): $17.50 ($5.83 / dz)
- Spectra Sure Plus IGR (3 dz): $19.99 ($6.67 / dz)
Summary
There are many generic versions of Frontline Plus for Dogs. The topical flea drops listed on this page all contain exactly the same active ingredient concentrations as Frontline Plus (9.8% fipronil and 8.8% methoprene).
DogMD Plus
DogMD Plus is a cheap alternative to Frontline Plus, with the same ingredients.
DogMD Plus is currently the cheapest alternative to Frontline Plus. On eBay, a 6 month supply costs $15 ($2.50 per dose). This is a significantly cheaper than Frontline Plus, which costs over $50 for 6 monthly treatments ($8.33 per dose).
Prices and availability are based on the time of publishing and are subject to change. Content on this page is meant for informational purposes only, with no guarantee of accuracy. For full product information visit the manufacturer’s or retailer’s websites. See more disclaimers.
Details
Frontline Plus for Dogs Active Ingredients
The active ingredients in Frontline Plus for Dogs are 9.8% fipronil and 8.8% (s)-methoprene. All of the generic alternatives listed below contain the same active ingredients, in the same concentrations. For full details, compare the product label of Frontline Plus to the generics’ labels (linked below).
Fipronil is an adulticide that quickly kills adult fleas on the treated dog. (s)-methoprene (also called Precor) is an insect growth regulator (IGR). It mimics natural insect hormones that regulate development and maturity. Flea eggs and larvae that are exposed to an IGR can’t mature into adults. And IGR-exposed adult females can’t lay eggs.
Generic Alternatives to Frontline Plus for Dogs
DogMD Plus
Dog MD Plus is the cheapest generic brand of Frontline Plus for sale on eBay.com. View product label
DogMD Plus is the cheapest alternative to Frontline Plus for Dogs. Like Frontline Plus, DogMD Plus contains 9.8% fipronil and 8.8% (s)-methoprene. There are four products, each corresponding to dogs of specific weight ranges: small dogs (4-22 lbs), medium dogs (23-44 lbs), large dogs (45-88 lbs), and x-large dogs (89-132 lbs). The flea drops should only be used on dogs over 8 weeks of age.
DogMD Plus comes in two package sizes, 3 or 6 monthly doses. The 6 dose package offers the best value, costing only $15 on eBay.com.
PetAction Plus for Dogs
PetAction Plus is another cheap generic version of Frontline Plus for Dogs, and the cheapest on Amazon. View product label
PetAction Plus for Dogs is another generic fipronil and methoprene treatment for dogs. It is equivalent to Frontline Plus in terms of active ingredient formulation. PetAction Plus comes in 4 products, which correspond to dogs of specific weights. It shouldn’t be used on dogs under 8 weeks of age.
PetAction Plus comes in two package sizes, 3 and 6 monthly doses. PetAction Plus stands out from other generic versions of Frontline Plus, because it is the cheapest option available on Amazon.com, costing around $16 for 3 monthly doses.
FiproGuard Plus for Dogs
FiproGuard Plus for Dogs is another relatively cheap alternative to Frontline Plus. View product label
Sentry Fiproguard Plus for Dogs doesn’t significantly differ from the generic alternatives to Frontline Plus that are mentioned above.
PetArmor Plus for Dogs
PetArmor Plus for Dogs is another somewhat cheap alternative to Frontline Plus. View product label
PetArmor Plus for Dogs doesn’t significantly differ from the other generic versions of Frontline Plus that are mentioned above.
Petlock Plus for Dogs
Petlock Plus for Dogs is another equivalent to Frontline Plus. View product label
Petlock Plus for Dogs doesn’t significantly differ from the other generic alternatives to Frontline Plus that are mentioned above.
ZoGuard Plus for Dogs
ZoGuard Plus for Dog is another Frontline Plus alternative. View product label
ZoGuard Plus for Dogs doesn’t significantly differ from the generic alternatives to Frontline Plus that are mentioned above.
FirstAct Plus for Dogs
FirstAct Plus for Dogs is another generic version of Frontline Plus. View product label
FirstAct Plus for Dogs doesn’t significantly differ from the generic alternatives to Frontline Plus that are mentioned above.
Pet Defender Plus for Dogs
Pet Defender Plus for Dogs is harder to find and more expensive than other options. View product label
Pet Defender Plus for Dogs doesn’t significantly differ from the generic alternatives to Frontline Plus that are mentioned above.
Spectra Sure Plus IGR for Dogs
Spectra Sure Plus for Dogs is another alternative to Frontline Plus, but isn’t the cheapest choice. View product label
Spectra Sure Plus for Dogs doesn’t significantly differ from the generic alternatives to Frontline Plus that are mentioned above.
Fiprotrol Plus for Dogs
Fiprotrol Plus is another Frontline Plus for dogs equivalent. View product label
Fiprotrol Plus for Dogs doesn’t significantly differ from the generic equivalents to Frontline Plus mentioned above.
Firstect Plus for Dogs
Firstect Plus for Dogs is a Frontline Plus equivalent, but is hard to find. View product label
Firstect Plus for Dogs doesn’t significantly differ from the generic alternatives to Frontline Plus that are mentioned above.
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Purchased ZOGUARD PLUS at COSTCO. Four boxes. It worked for about ten days and then pets were covered in fleas. My pets had NO FLEAS OR TICKS before that because we live in Las Vegas where there are no ticks/fleas.